Effect of Cyclosporine A on some Blood Parmeters, Liver and Kidney Function Enzymes and the protective role of Cinnamon extract in rabbits

Abstract

This study investigated the biochemical and hematological effects of cyclosporine A (CsA) and the protective role of cinnamon extract in rabbits. Cyclosporine A, an immunosuppressant used in transplantation, is known to cause organ toxicity, especially in the liver and kidneys, often through oxidative stress. Our results showed that CsA treatment significantly decreased total protein and albumin, indicating compromised liver function. It also caused significant increases in liver enzymes (AST, ALT, LDH) and bilirubin, all signs of substantial liver damage. Furthermore, CsA led to reductions in red blood cell count and hemoglobin, affecting hematological parameters.Notably, co-administration of cinnamon extract effectively mitigated these adverse effects. Cinnamon is recognized for its antioxidant and anti-inflammatory properties, which counteract CsA-induced oxidative stress. The extract helped normalize liver enzyme levels and improved hematological parameters, demonstrating its protective efficacy against CsA-induced toxicity. This highlights cinnamon's potential as a natural adjunct to lessen the side effects of cyclosporine A therapy.