Antimicrobial activity of Medicinal plant extracts: A Review Article
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Abstract
The inappropriate uses of antibiotics have led to antimicrobial resistance, making various currently available antibiotics ineffective. Thus, there is an increasing need for the development of new antimicrobial materials that can reduce antibiotics use and overcome the emergence of resistance. Medicinal Plants could be a promising solution for fighting against disease. They contain variety of bioactive compounds such as alkaloids, quinones, tannins, terpenoids, flavonoids, and polyphenols, that have proved to have antimicrobial activity. demonstrate broad-spectrum antimicrobial activity through multiple mechanisms including membrane disruption, cell wall interference, inhibition of protein and nucleic acid synthesis, reactive oxygen species generation, and anti-virulence effects. Recent studies document measurable antimicrobial potency with minimum inhibitory concentrations in the low microgram per milliliter range against clinically relevant pathogens, including multidrug-resistant strains. They may inhibit the growth of bacteria, viruses and fungi by different mechanisms. This review explores the antimicrobial activity of bioactive compounds of medicinal plants and their possible mechanisms of action
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References
Prestinaci F, Pezzotti P, Pantosti A. (2015). Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health.109(7):309-18. doi: 10.1179/2047773215Y.
Baym, M.; Stone, L.; Kishony, R.(2015). Multidrug Evolutionary Strategies to Reverse Antibiotic Resistance. Science, 351, aad3292. doi: 10.1126 /science.aad3292
Davies, J.; Davies, D.(2010). Origins and Evolution of Antibiotic Resistance. Microbiol. Mol. Biol. Rev. 2010, 74, 417–433. doi: 10.1128/MMBR.00016-10
Mcewen, S. A., and Collignon, P. J.(2018). Antimicrobial resistance: a one health perspective. Microbiol. Spectr. 6. doi:10.1128/microbiolspec.ARBA-0009-2017
O’Neill, J .(2016). Tackling drug-resistant infections globally: final report and recommendations: Review on Antimicrobial Resistance . doi: 10.1136/ejhpharm-2016-001013
Khameneh, B. Diab, R.; Ghazvini, K. Fazly Bazzaz, B. (2016). Breakthroughs in Bacterial Resistance Mechanisms and the Potential Ways to Combat them. Microb. Pathogen. 2016, 95, 32–42. doi.org/10.1016/j.micpath.2016.02.009.
Tortorella, E.; Tedesco, P.; Palma Esposito, F.; January, G.; Fani, R.; Jaspars, M.; de Pascale, D.(2018). Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Mar. Drugs, 16, 355. doi: 10.3390/md16100355.
Penesyan, A.; Kjelleberg, S.; Egan, S.( 2010). Development of Novel Drugs from Marine Surface Associated Microorganisms. Mar. Drugs, 8, 438–459, doi: 10.3390/md8030438.
Talib, W.H.(2011). Anticancer and Antimicrobial Potential of Plant-Derived Natural Products. In Phytochemicals—Bioactivities and Impact on Health; Rasooli, I., Ed.; IntechOpen: London, UK, pp. 141–158, DOI: 10.5772/26077.
Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. (2019). A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites. 1;9(11): 258.. PMID: 31683833; PMCID: PMC6918160, doi: 10.3390/metabo9110258.
Hashemi,S.R.,andDavoodi,H.(2011).Herbal plants and their derivatives as growth and health promoters in animal nutrition. Vet.Res.Commun. 35, 169–180. doi: 10.1007/s11259-010-9458-2.
Savoia,D.(2012).Plant-derivedantimicrobialcompounds:alternativestoantibi-otics. FutureMicrobiol..7, 979–990.doi:10.2217/fmb.12.68.
Vondruskova,H.,Slamova,R.,Trckova,M.,Zraly,Z.,andPavlik,I.( 2010).Alternatives to antibiotic growth promoters in prevention of diarrhea in weaned piglets: a review. Vet.Med.. 55, 199–224, DOI: 10.17221/2998-VETMED.
Huyghebaert,G.,Ducatelle,R.,andVanImmerseel,F.( 2011). An update on alter- natives to antimicrobial growth promoters for broilers. Vet.J. 187, 182–188.doi: 10.1016/j.tvjl.2010.03.003.
Windisch,W.,Schedle,K.,Plitzner,C.,and Kroismayr,A.( 2008).Use of phytogenic products as feed additives for swine and poultry. J. Anim.Sci. .86(Suppl.), E140– E148. doi:10.2527/jas.2007-0459.
Metrouh-Amir, H., Duarte, C. M. M., and Maiza, F. (2015). Solvent effect on total phenolic contents, antioxidant, and antibacterial activities of Matricaria pubescens. Ind. Crop. Prod. 67, 249–256, DOI: 10.1016/j.indcrop.2015.01.049.
Yetgin, A. (2024). Investigating medicinal plants for antimicrobial benefits in a changing climate.Int. J. Secondary Metabolite, 11 pp. 364-377, 10.21448/ijsm.1279531, https://doi.org/10.21448/ijsm.1279531.
[‘-C. F. Carson, K. A. Hammer, and T. V. Riley. (2006). Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties. Clinical microbiology reviews, 19(1), 50–62, DOI: 10.1128/CMR.19.1.50-62.2006.
Yaseen Hussain, Waqas Alam, Hammad Ullah, Marco Dacrema, Maria Daglia, Haroon Khan and Carla Renata Arciola. (2022). Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications. Antibiotics 11, 322, https://doi.org/10.3390/antibiotics11030322.
Agnieszka Magryś, Alina Olender, Dorota Tchórzewska. (2021). Antibacterial properties of Allium sativum L. against the most emerging multidrug resistant bacteria and its synergy with antibiotics. Archives of Microbiology. 203:2257–2268, DOI: 10.1007/s00203-021-02248-z.
Cowan, M. M. (1999). "Plant products as antimicrobial agents." Clinical Microbiology Reviews, 12(4), 564-582, doi: 10.1128/CMR.12.4.564.
Al-Bayatti, KK, Aziz, FM, Abdalah, ME.(2012). A Study of Antibacterial Activity of Cidar (Zizyphus spinachristi L.) on Bacterial Pathogens isolated from Skin Infections.Al Mustansiriyah Journal of Pharmaceutical Sciences 9 (1), 13-20, DOI: https://doi.org/10.32947/ajps.v9i1.268.
Abdallah EM, Qureshi KA, Ali AM, Elhassan GO. (2017). Evaluation of some biological properties of Saussurea costus crude root extract. Biosci. Biotechnol. Res. Commun. 2017 Oct 1;10(4):601-11, DOI: 10.21786/bbrc/10.4/2.
Aziz.FM. (2010). The Study of Antibacterial Activity of Juglans Regia and Thymus Vulgaris Seeds AJPS, Vol. 7, No.1, DOI: https://doi.org/10.32947/ajps.v7i1.318.
O’Mahony R, Al-Khtheeri H, Weerasekera D, Fernando N, Vaira D, Holton J, Basset C.( 2005). Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World journal of gastroenterology. Dec 21;11(47):7499, doi: 10.3748/wjg.v11.i47.7499.
Rani P, Khullar N. (2004). Antimicrobial evaluation of some medicinal plants for their anti‐enteric potential against multi‐drug resistant Salmonella typhi. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. Aug;18(8):670-3, DOI: 10.1002/ptr.1522.
Manandhar, S.; Luitel, S.; Dahal, R. ( 2019). In Vitro Antimicrobial Activity of Some Medicinal Plants against Human Pathogenic Bacteria. J. Trop. Med., , 1–5, DOI: 10.1155/2019/1895340.
Reichling, J.; Schnitzler, P.; Suschke, U.; Saller, R. (2009). Essential Oils of Aromatic Plants with Antibacterial, Antifungal, Antiviral, andCytotoxic Properties-An Overview. Forsch Komplementmed, 16, 79–90, DOI: 10.1159/000207196.
Sienkiewicz, M.; Łysakowska, M.; Cie´cwierz, J.; Denys, P.; Kowalczyk, E. (2011). Antibacterial Activity of Thyme and Lavender EssentialOils. Med. Chem., 7, 674–689 , DOI: 10.2174/157340611797928488.
Gonelimali FD, Lin J, Miao W,Xuan J, Charles F, Chen M and Hatab SR.( 2018). Antimicrobial Properties and Mechanism of Action of Some Plant Extracts Against Food Pathogens and Spoilage Microorganisms.Front. Microbiol. 9:1639. doi: 10.3389/fmicb.2018.01639.
Ushimaru PI, Silva MT, Di Stasi LC, Barbosa L, Fernandes Junior A. Antibacterial activity of medicinal plant extracts. Brazilian Journal of Microbiology. 2007;38:717-9. doi.org/10.1590/S1517-83822007000400024.
Faye G, Birhanu T, Belete T. (2021). Survey and Antimicrobial Activity Study of Ethnomedicinal Plants in Selected Districts of North Shewa Zone, Oromia, Ethiopia. Infect Drug Resist. Dec 18;14:5511-5520. doi: 10.2147/IDR.S333772. PMID: 34955645; PMCID: PMC8694572.
Meshaal AK, Hetta HF, Yahia R, Abualnaja KM, Mansour AT, Al-Kadmy IMS, Alghamdi S, Dablool AS, Emran TB, Sedky H, Batiha GE-S, El-Kazzaz W. (2021). In Vitro Antimicrobial Activity of Medicinal Plant Extracts against Some Bacterial Pathogens Isolated from Raw and Processed Meat. Life. 11(11):1178. https://doi.org/10.3390/life11111178.
Sánchez E, Rivas Morales C, Castillo S, Leos-Rivas C, García-Becerra L, Mizael Ortiz Martínez D. (2016). "Antibacterial and Antibiofilm Activity of Methanolic Plant Extracts against Nosocomial Microorganisms", Evidence-Based Complementary and Alternative Medicine, vol. 2016. doi: 10.1155/2016/1572697.
Ekor, M. (2014). The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety." Frontiers in Pharmacology, 4, 177. doi: 10.3389/fphar.2013.00177
Nanbiao and Fang Li. (2024). Antifungal Mechanism of Natural Products Derived from Plants: A Review. Natural Product Communications. Volume 19(8).1-12. DOI: 10.1177/1934578X241271747.
Adepoju A O, Ogunkunle A.T. and Femi-Adepoju A. G. (2014). Antifungal Activities Of Seed Oil Of Neem (Azadirachta indica A. Juss.). G.J.B.A.H.S., 3(1):106-109
Kalpa Oza, B. K. Jain and Bharat Maitreya. (2021). Antifungal Activity of Turmeric (Curcuma longa) Rhizome against Different Fungal. Indian Journal of Natural Sciences. 11(64).
Serge Ankri, David Mirelman. (1999). Antimicrobial properties of allicin from garlic. Microbes and Infection, ,2, 125−129
Mertas A, Garbusińska A, Szliszka E, Jureczko A, Kowalska M, Król W. (2015). The influence of tea tree oil (Melaleuca alternifolia) on fluconazole activity against fluconazole-resistant Candida albicans strains. Biomed Res Int. 2015:590470. doi:10.1155/2015/590470
-Wylie MR, Merrell DS. (2022). The Antimicrobial Potential of the Neem Tree Azadirachta indica. Front Pharmacol. 30;13:891535. doi: 10.3389/fphar.2022.891535.
-Tejada-Muñoz S, Cortez D, Rascón J, Chavez SG, Caetano AC, Díaz-Manchay RJ, Sandoval-Bances J, Huyhua-Gutierrez S, Gonzales L, Chenet SM, et al. (2024). Antimicrobial Activity of Origanum vulgare Essential Oil against Staphylococcus aureus and Escherichia coli. Pharmaceuticals, 17(11):1430. doi.org/10.3390/ph17111430
-Nathaniel Hiwandika, Susana Elya Sudrajat, & Rahayu, I. (2021). Antibacterial and Antifungal Activity of Clove Extract (Syzygium Aromaticum): Review. Eureka Herba Indonesia, 2(2), 86-94. doi.org/10.37275/ehi.v2i2.18
- Nieto G, Ros G, Castillo J. (2018). Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review. Medicines (Basel), 4;5(3):98. doi: 10.3390/medicines5030098.
-Olivas-Méndez P, Chávez-Martínez A, Santellano-Estrada E, Guerrero Asorey L, Sánchez-Vega R, Rentería-Monterrubio AL, Chávez-Flores D, Tirado-Gallegos JM, Méndez-Zamora G. (2022). Antioxidant and Antimicrobial Activity of Rosemary (Rosmarinus officinalis) and Garlic (Allium sativum) Essential Oils and Chipotle Pepper Oleoresin (Capsicum annum) on Beef Hamburgers. Foods, 11(14):2018. doi.org/10.3390/foods11142018
-Bachir RG, Benali M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pac J Trop Biomed., 2(9):739-42. doi: 10.1016/S2221-1691(12)60220-2.
-Radji M, Agustama RA, Elya B, Tjampakasari CR. (2013). Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa. Asian Pac J Trop Biomed, 3(8):663-7. doi: 10.1016/S2221-1691(13)60133-1.
-Bassiri-Jahromi S, Pourshafie MR, Mirabzade Ardakani E DVM, Ehsani AH, Doostkam A, Katirae F, Mostafavi E. (2018). In Vivo Comparative Evaluation of the Pomegranate (Punica granatum) Peel Extract as an Alternative Agent to Nystatin against Oral Candidiasis. Iran J Med Sci., 43(3):296-304. PMID: 29892147; PMCID: PMC5993896.
-Forouzanfar F, Bazzaz BS, Hosseinzadeh H. (2014). Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects. Iran J Basic Med Sci, 17(12):929-38. PMID: 25859296; PMCID: PMC4387228.
-Al-Rubiay KK, Jaber NN; Al-Mhaawe BH, Alrubaiy LK. (2008). Antimicrobial efficacy of henna extracts. Oman Med J,.23(4):253-256. Doi;10.4314/bajopas.v11i1.27S
-Haque SD, Saha SK, Salma U, Nishi MK, Rahaman MS .( 2019).Antibacterial Effect of Aloe vera (Aloe barbadensis) leaf gel against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Mymensingh Med J, 28(3):490-496.
Gabriel A., Eureka E., and Osbourne Q. (2024). Medicinal Plants as Effective Antiviral Agents and Their Potential Benefits. Natural Product Communications. 19(9). DOI: 10.1177/1934578X241282923.
Al-Snafi AE. (2023). Medicinal plants with antiviral effect: A review. GSC Biological and Pharmaceutical Sciences,.24(01), 098–113 doi.org/10.30574/gscbps.2023.24.1.0275.
Cinatl, J., Morgenstern B, Bauer G , Chandra P , Rabenau H, Doerr HW. (2003). "Glycyrrhizin, an active component of licorice root, and replication of SARS-associated coronavirus." The Lancet, 361(9374), 2045-2046. doi: 10.1016/S0140-6736(03)13615-X
Zakay-Rones Z, Thom E, Wollan T and Wadsten J. (2004). "Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections." Journal of International Medical Research, 32(2), 132-140. doi: 10.1177/147323000403200205.
Jiang M, Sheng F, Zhang Z, Ma X, Gao T, Fu C, Li P.( 2021). Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents. J Ethnopharmacol. 23;272:113954. doi: 10.1016/j.jep.2021.113954
Wu CY, Yu ZY, Chen YC, Hung SL. (2021). Effects of epigallocatechin-3-gallate and acyclovir on herpes simplex virus type 1 infection in oral epithelial cells. J Formos Med Assoc. 120(12):2136-2143. doi.org/10.1016/j.jfma.2020.12.018.
Verpoorte, R. (1998). Exploration of Nature’s Chemodiversity: The Role of Secondary Metabolites as Leads in Drug Development. Drug Discov. Today 3, 232–238. doi:10.1016/S1359-6446(97)01167-7
Mahmood, Z.A.; Mahmood, S.B.Z. (2013). Antibiotic Natural Products: Opportunities and Challenges. In Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education; Méndez-Vilas, A., Ed.; Colorcon Limited: Dartford Kent, UK, 2013; pp. 823–833.doi: 10.1016/B978-0-12-415804-8.00074-9
Morrissey,J.P.,andOsbourn,A.E. (1999). Funga lresistance to plant antibiotics as a mechanism of pathogenesis. Microbiol.Mol.Biol.Rev.. 63, 708–724, doi: 10.1128/MMBR.63.3.708-724.1999.
Iwasa, K.; Moriyasu, M.; Yamori, T.; Turuo, T.; Lee, D.-U.;Wiegrebe,W. (2001). In Vitro Cytotoxicity of the Protoberberine-Type Alkaloids.J. Nat. Prod., 64, 896–898, https://doi.org/10.1021/np000554f.
Yi, Z.B.; Yan, Y.; Liang, Y.Z.; Zeng, B. (2007). Evaluation of the Antimicrobial Mode of Berberine by LC/ESI-MS Combined with Principal Component Analysis. J. Pharm. Biomed. Anal., 44, 301–304, doi: 10.1016/j.jpba.2007.02.018.
Daglia, M. (2012). Polyphenols as antimicrobial agents. Curr. Opin. Biotechnol. 23, 174–181, doi: 10.1016/j.copbio.2011.08.007.
Schmidt, T.J.; Khalid, S.A.; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, F.B.;De Castro, S.L.; Ferreira, V.F.; De Lacerda, M.V.G.; et al. (2012). The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II. Curr. Med. Chem., 19, 2176–2228, doi: 10.2174/092986712800229023.
Li, A.-N.; Li, S.; Zhang, Y.-J.; Xu, X.-R.; Chen, Y.-M.; Li, H.-B. (2014). Resources and biological activities of natural polyphenols. Nutrients, 6, 6020–6047, doi: 10.3390/nu6126020.
Friedman, M.; Henika, P.R.; Levin, C.E.; Mandrell, R.E.; Kozukue, N. (2006). Antimicrobial Activities of Tea Catechins and Theaflavins and Tea Extracts against Bacillus cereus. J. Food Prot., 69, 354–361, doi: 10.4315/0362-028x-69.2.354.
Betts, J.W.; Kelly, S.M.; Haswell, S.J. (2011). Antibacterial Effects of Theaflavin and Synergy with Epicatechin against Clinical Isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia. Int. J. Antimicrob. Agents, 38, 421–425, doi: 10.1016/j.ijantimicag.2011.07.006.
Cisowska, A.;Wojnicz, D.; Hendrich, A.B. (2011). Anthocyanins as Antimicrobial Agents of Natural Plant Origin. Nat. Prod. Commun., 6, 149–156, doi: 10.1177/1934578X1100600136.
Bouarab-Chibane, L.; Forquet, V.; Lantéri, P.; Clément, Y.; Léonard-Akkari, L.; Oulahal, N.; Degraeve, P.; Bordes, C. (2019). Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure–Activity Relationship)Models. Front. Microbiol., 10,829, doi.org/10.3389/fmicb.2019.00829.
Farhadi, F.; Khameneh, B.; Iranshahi, M.; Iranshahy, M. . (2019). Antibacterial Activity of Flavonoids and Their Structure–Activity Relationship: An Update Review. Phytother. Res, 33, 13–40, doi: 10.1002/ptr.6208.
Górniak, I.; Bartoszewski, R.; Króliczewski, J.( 2019). Comprehensive Review of Antimicrobial Activities of Plant Flavonoids. Phytochem. Rev., 18, 241–272, doi.org/10.1007/s11101-018-9591-z.
Gutiérrez-Venegas G, Gómez-Mora JA, Meraz-Rodríguez MA, Flores-Sánchez MA, Ortiz-Miranda LF. (2019). Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque. Heliyon. Dec 13;5(12): e03013, doi: 10.1016/j.heliyon.2019.e03013.
de Freitas Araújo, M.G.; Hilário, F.; Nogueira, L.G.; Vilegas, W.; dos Santos, L.C.; Bauab, T.M. (2011). Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix Spiralis Ruhland and Their Antimicrobial Activity. Molecules, 16, 10479–10490, doi: 10.3390/molecules161210479.
García, A.; Bocanegra-García, V.; Palma-Nicolás, J.P.; Rivera, G. (2012). Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem., 49, 1–23, doi: 10.1016/j.ejmech.2011.12.029.
Kaczmarek B. (2020). Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials-A Minireview. Materials (Basel). 20;13(14):3224, doi: 10.3390/ma13143224.
Cushnie, T.P.T.; Lamb, A.J. (2005). Antimicrobial Activity of Flavonoids. Int. J. Antimicrob. Agents 26, 343–356, DOI: 10.1016/j.ijantimicag.2005.09.002
Engels, C.; Schieber, A.; Gänzle, M.G. (2011). Inhibitory Spectra and Modes of Antimicrobial Action of Gallotannins from Mango Kernels (Mangifera indica L.). Appl. Environ. Microbiol., 77, 2215–2223.], doi: 10.1128/AEM.02521-10
Scalbert, A. (1991). Antimicrobialpropertiesoftannins. Phytochemistry, 30, 3875– 3883. doi:10.1016/0031-9422(91)83426-L
Smyth, T.; Ramachandran, V.N.; Smyth, W.F. A Study of the Antimicrobial Activity of Selected Naturally Occurring and Synthetic Coumarins. Int. J. Antimicrob. Agents, 33, 421–426, doi: 10.1016/j.ijantimicag.2008.10.022
Basile, A.; Sorbo, S.; Spadaro, V.; Bruno, M.; Maggio, A.; Faraone, N.; Rosselli, S. (2009). Antimicrobial and Antioxidant Activities of Coumarins from the Roots of Ferulago Campestris (Apiaceae). Molecules 2009, 14, 939–952, DOI: 10.3390/molecules14030939.
Tan, N.; Yazıcı-Tütüni¸s, S.; Bilgin, M.; Tan, E.; Miski, M. (2017). Antibacterial Activities of Pyrenylated Coumarins from the Roots of PrangosHulusii. Molecules, 22, 1098. 107, DOI: 10.3390/molecules22071098
Maxwell, A. (1993).The Interaction between Coumarin Drugs and DNA Gyrase. Mol. Microbiol., 9, 681–686, DOI: 10.1111/j.1365-2958.1993.tb01728.x
Zhang, Y.; Sass, A.; Van Acker, H.;Wille, J.; Verhasselt, B.; Van Nieuwerburgh, F.; Kaever, V.; Crabbé, A.; Coenye, T. Coumarin. (2018). Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-Di-GMP Levels. Front. Microbiol., 9, 1952, https://doi.org/10.3389/fmicb.2018.01952
Reen, F.J.; Gutiérrez-Barranquero, J.A.; Parages, M.L.; O Gara, F. (2018). Coumarin: A Novel Player in Microbial Quorum Sensing and Biofilm Formation Inhibition. Appl. Microbiol. Biotechnol., 102, 2063–2073, DOI: 10.1007/s00253-018-8787-x
Copp, B.R. (2003). Antimycobacterial Natural Products. Nat. Prod. Rep., 20, 535–557, DOI: 10.1039/b212154a.
Vaou N, Stavropoulou E, Voidarou C, Tsigalou C, Bezirtzoglou E. (2021). Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms. Sep 27;9(10):2041, doi: 10.3390/microorganisms9102041
Vaou.N, Stavropoulou E, Voidarou CC, Tsakris Z, Rozos G, Tsigalou C, Bezirtzoglou E. (2022). Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects. Antibiotics (Basel). Jul 28;11(8):1014, DOI: 10.3390/antibiotics11081014
World Health Organization. (2021). WHO guidelines on safety monitoring of herbal medicines.
Cristiane Fernandes Lisboa,et al. (2022). Packaging and storage of medicinal plants. Research Society and Development., v. 11, n. 7, e50911724813, 2022, DOI: 10.33448/rsd-v11i7.24813.
Gilbert U. Adie, Chidiebere Chinonso Ogbonna. (2022). Chemical and microbial contamination of herbal remedies and their potential health implications: A review. Proceedings of the International Academy of Ecology and Environmental Sciences, , 12(2): 54-73, doi: 10.1016/j.heliyon.2023.e19370
Guangfei Wei , Xiaotong Guo et al., (2023). Occurrence of fungi and mycotoxins in herbal medicines and rapid detection of toxin-producing fungi.Environmental Pollution;. Volume 333, 122082, https://doi.org/10.1016/j.envpol.2023.122082.