Knowledge and Practice of Dentists Regarding Prescribing of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Yemen: A Cross-sectional Analysis
Keywords:
NSAIDs, Knowledge, Practice, Yemen, DentistsAbstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are crucial in dental therapy, as they effectively control pain and inflammation following dental operations. Nevertheless, there is a dearth of study on the understanding of Yemeni dentists regarding the prescription of NSAIDs in their daily practice. This study aimed to address this knowledge gap by evaluating these parameters among dentists from Yemen. A cross-sectional survey was done between February and March 2023, with 123 Yemeni dentists recruited. Information was gathered from dentists working in either the private or public sectors in Aden and Taiz governorates, Yemen. Participants filled out an internet-based questionnaire using Google Forms which consisted of 12-items that evaluated their knowledge of the indications, contraindications, and side effects of NSAIDs in the field of dentistry. The data was examined using SPSS software, specifically version 26. The study recruited 123 participants, the majority were males (56.1%), young individuals (60.9%), with less than five years of professional experience (66.6%), and employed in private clinics (64.2%) with a low number of dental procedures performed on a weekly basis. Based on our results, NSAIDs were often given for dental pain after surgery (97.6%), tooth removal (83.7%), and periodontitis (71.5%). The majority of prescriptions had a duration of 5 to 10 days, accounting for 60.1% of cases. In addition, only 10.6% of dentists disclosed probable adverse effects to their patients. Even among patients who experienced negative effects, almost 50% reported merely gastrointestinal problems. Approximately 71.5% of dentists demonstrated a lack of understanding on the appropriate dosage of NSAIDs for children and pregnant women. This study revealed a concerning deficiency of knowledge among dentists on the appropriate dosage of NSAIDs among pregnant women and children. Although NSAID prescriptions were effective for addressing various types of dental pain, there was a significant deficiency in communicating the potential side effects. These findings emphasize the immediate necessity for educational programs for dental students and practicing dentists might enhance their understanding of evidence-based NSAID therapy.
References
Mullan J, Weston KMBA, Burns P, Mullan J, Rudd R. Consumer knowledge about over-the-counter NSAIDs: they don’t know what they don’t know. Aust New Zealand J Public Health. 2017;41(2):210.
Fortune Business Insights. NSAIDs Market to Reach USD 24.35 Billion by 2027; Surging Research on Selective Cyclooxygenase-2 Inhibitors to Boost Growth. 2020. https://www.globenewswire.com/news-release/2020/05/28/2040374/0/en/NSAIDs-Market-to-Reach-USD-24-35-Billion-by-2027-Surging-Research-on-Selective-Cyclooxygenase-2-Inhibitors-to-Boost-Growth-Fortune-Business-Insights.html#:~:text=Filings%20Media%20Partners-,NSAIDs%20Market%20to%20Reach%20USD%2024.35%20Billion%20by%202027%3B%20Surging,Growth%3A%20Fortune%20Business%20Insights%E2%84%A2. Accessed 13 Oct 2020.
Negm AA, Furst DE. Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics, & drugs used in Gout. In: Katzung BG, editor. Basic and Clinical Pharmacology. 14th ed. New York: McGraw-Hill; 2017.
Mazzarino M, Braganò MC, Donati F, de la Torre X, Botrè F. Effects of propyphenazone and other non-steroidal anti-inflammatory agents on the synthetic and endogenous androgenic anabolic steroids urinary excretion and/or instrumental detection. Anal Chim Acta. 2010;657(1):60–8.
Davis A, Robson J. The dangers of NSAIDs: look both ways. Br J Gen Pract. 2016;66(645):172–3.
Wazaify M, Hughes CM, McElnay JC. The implementation of a harm minimisation model for the identification and treatment of over-the-counter drug misuse and abuse in community pharmacies in Northern Ireland. Patient Educ Couns. 2006;64(1–3):136–41.
Gunaydin C, Bilge SS. Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level. Eurasian J Med. 2018 Jun;50(2):116-121.
Borer JS, Simon LS. Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance. Arthritis Res Ther. 2005;7 Suppl 4(Suppl 4):S14-22.
Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020 Oct;180:114147.
Goodman LS. Goodman & Gilman's Pharmacological Basis of Therapeutics. McGraw-Hill, New York, NY, 2018. Guzmán-Álvarez R, Medeiros M, Lagunes LR, CamposSepúlveda AE. Knowledge of drug prescription in dentistry students. Drug Healthc Patient Saf, 2012; 4:55.
Kim SJ, Seo JT. Selection of analgesics for the management of acute and postoperative dental pain: a mini-review. J Periodontal Implant Sci. 2020 Mar 19;50(2):68-73.
Segura Egea JJ, Martín González J, Jiménez Sánchez MDC, Crespo Gallardo I, Saúco Márquez JJ, Velasco Ortega E. Knowledge and pattern of antibiotic and non narcotic analgesic prescription for pulpal and periapical pathologies-A survey among dentists. J Clin Diagn Res, 2014; 8(7):ZC10
Datta R, Grewal Y, Batth JS, Singh A. A survey of analgesic and anti-inflammatory drug prescription for oral implant surgery. Plast Aesthet Res, 2015; 2:51–5.
Alharbi AO, Almjayishi SA, Aldarwish RI, Almeshari MA, Aljumydi MT, Faraj RM. Knowledge About and the Use of Oral Nonsteroidal Anti-inflammatory Drugs Among Patients With Rheumatic Disorders in Saudi Arabia: A Cross-Sectional Study. Cureus. 2023 Nov 8;15(11):e48500.
Al-Wesabi, M. A., Al-Sanaani, S., & Al-Hajjawi, S. A. (2017). Drug Prescription Knowledge and Practices among Dental Students and Interns Enrolled in Selected Yemeni Universities. Yemen Journal of Medical Sciences, 11(1), 15-23. [1]
Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, Konstam MA. Adenomatous polyp prevention on vioxx trial I. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med, 2015; 352(11):1092–102.
Hoxha, M., Malaj, V., Spahiu, E., & Spahiu, M. (2020). Dentists knowledge about over the counter-NSAIDs: an emerging need for NSAID-Avoidance Education. Journal of Applied Pharmaceutical Science, 10(1), 070-076.
Finsen, L., Christensen, H., & Bakke, M. (1998). Musculoskeletal disorders among dentists and variation in dental work. Applied ergonomics, 29(2), 119-125.
Şermet, S., Akgün, M. A., & Şimşek, Ş. (2012). Analgesic prescription pattern in the management of dental pain among dentists in İstanbul. Marmara Pharmaceutical Journal, 16(1), 41-47.
Myers, A., Gelotte, C., Zuckerman, A., Zimmerman, B., Shenoy, A., Qi, D., & Cooper, S. A. (2024). Analgesic onset and efficacy of a fast-acting formulation of acetaminophen in a postoperative dental impaction pain model. Current Medical Research and Opinion, 40(2), 267–277.
American Dental Association [ADA]. (2023).Retrieved from https://www.ada.org/
Ali S, Sofi K, Dar AQ. Comparison of Intravenous Infusion of Tramadol Alone with Combination of Tramadol and Paracetamol for Postoperative Pain after Major Abdominal Surgery in Children. Anesth Essays Res. 2017 Apr-Jun;11(2):472-476.
Pipalia, P. R., Annegeri, R. G., Juturu, T., & Mehta, R. (2016). Control of odontogenic pain by diclofenac and meloxicam mucoadhesive patches: A randomized, double-blinded, placebo-controlled, preliminary study. Journal of Indian Academy of Oral Medicine and Radiology, 28(3), 229-235.
PragyaPandey, A. P. T., Bharti, R., Jha, P., Singh, D., & Kudva, S. (2021). Knowledge of Pregnant Women in Regards to Oral Health of the Expected Child. Indian Journal of Forensic Medicine & Toxicology, 15(2), 559.
Dionne, R. A., Gordon, S. M., & Moore, P. A. (2016). Prescribing opioid analgesics for acute dental pain: time to change clinical practices in response to evidence and misperceptions. Compend Contin Educ Dent, 37(6), 372-378.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
